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Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/16191
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dc.contributor.authorWang, Hui-fei-
dc.contributor.authorRun Gan-
dc.contributor.authorJing Zhou-
dc.contributor.authorQi Liao-
dc.contributor.authorWang, Tian-bao-
dc.contributor.authorZhong, Cai-ling-
dc.contributor.authorXiang, Yuan-yuan-
dc.contributor.authorLin, Hong-bo-
dc.contributor.authorHu, Xiang-nan-
dc.date.accessioned2023-01-20T05:19:38Z-
dc.date.available2023-01-20T05:19:38Z-
dc.date.issued2018-07-20-
dc.identifier.citationWang, H. F., Gan, R., Zhou, J., Liao, Q., Wang, T. B., Zhong, C. L., ... & Hu, X. N. (2018). A facile method for the synthesis of 2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid and it's optimization. Pakistan Journal of Pharmaceutical Sciences, 31(4).en_US
dc.identifier.issn1011-601X-
dc.identifier.urihttp://142.54.178.187:9060/xmlui/handle/123456789/16191-
dc.description.abstract2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid (IV), a key intermediate of saxagliptin for type 2 diabetes mellitus (T2DM), was prepared from 1-adamantanecarboxylic acid(I) via oxidation by potassium permanganate(KMnO4) to afford 3-hydroxy-1-adamantanecarboxylic acid (II), which was treated with a one-pot method to give 1-acetyl-3-hydroxyadamantane (III) followed by oxidation. Some key steps were optimized and the overall yield was about 51%en_US
dc.language.isoenen_US
dc.publisherKarachi: Pakistan Botanical Society, University of Karachien_US
dc.subjectDiabetesen_US
dc.subjectkey intermediateen_US
dc.subjectsaxagliptinen_US
dc.subjectoptimizationen_US
dc.subjectone-pot method.en_US
dc.titleA facile method for the synthesis of 2-(3-hydroxy-1-adamantyl)-2oxoacetic acid and it’s optimizationen_US
dc.typeArticleen_US
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