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http://142.54.178.187:9060/xmlui/handle/123456789/16252| Title: | Synthesis of novel derivatives of 4-Pyridine carboxylic acid hydrazide and their activity on central nervous system |
| Authors: | Sabahat Naeem Shamim Akhtar Nousheen Mushtaq Arfa Kamil Shaista Zafar Sana Anwar Muhammad Arif |
| Keywords: | : 4-Pyridine carboxylic acid hydrazide Sulphonyl and benzoyl chloride Pharmacological screening |
| Issue Date: | 2-Sep-2014 |
| Publisher: | Karachi: Faculty of Pharmacy, University of Karachi |
| Citation: | Naeem, S., Akhtar, S., Mushtaq, N., Kamil, A., Zafar, S., Anwar, S., & Arif, M. (2014). Synthesis of novel derivatives of 4-Pyridine carboxylic acid hydrazide and their activity on central nervous system. Pakistan Journal of Pharmaceutical Sciences, 27(5), 1401-1409. |
| Abstract: | : Six novel derivatives (2-7) of 4-Pyridine carboxylic acid hydrazide (PCH) were synthesized by treating this lead molecule with substituted arylsulphonyl and benzoyl chlorides. The molecular structures of the newly derived products were characterized by the help of UV Visible, IR, FAB, 1 HNMR spectroscopy and CHN analysis. During the preliminary pharmacological screening, it was observed that the synthesized compounds induced noticeable changes on motor activity of the animals. Interesting structure activity relationship was also observed among the synthesized molecules. Because of the interesting affect on motor activity, the newly synthesized derivatives can further be evaluated for their effects on CNS |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/16252 |
| ISSN: | 1011-601X |
| Appears in Collections: | Issue No.5 (Special) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| SP-Paper-2.htm | 142 B | HTML | View/Open |
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