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dc.contributor.authorRaheela Khursheed-
dc.contributor.authorGhazala H Rizwani-
dc.contributor.authorViqar Sultana-
dc.contributor.authorMaryam Ahmed-
dc.contributor.authorArfa Kamil-
dc.date.accessioned2023-01-20T06:08:40Z-
dc.date.available2023-01-20T06:08:40Z-
dc.date.issued2014-09-04-
dc.identifier.citationKhursheed, R., Rizwani, G. H., Sultana, V., Ahmed, M., & Kamil, A. (2014). Antidepressant effect and categorization of inhibitory activity of monoamine oxidase type A and B of ethanolic extract of seeds of Trigonella foenum graecum Linn. Pakistan journal of pharmaceutical sciences, 27.en_US
dc.identifier.issn1011-601X-
dc.identifier.urihttp://142.54.178.187:9060/xmlui/handle/123456789/16255-
dc.description.abstractTrigonella foenum- graecum Linn (Fabaceae) is an annual aromatic herb and no wit is cultivated globally like in Pakistan, Egypt, India, Middle East etc. Traditionally it was used in anorexia, as febrifuge, to soothe gastritis and gastric ulcers, as a galactagogue and as condiment, hypoglycemic agent and employed in various as nervous disorders. The study aimed to investigate the antidepressant effect of ethanolic extract of seeds of Trigonella foenum graecum and underlying mechanism of action. For assessment of antidepressant activity Forced Swimming Test (FST), Tail Suspension Test (TST), Monoamine (MAO) Assay and Locomotor Activity Test were studied. Acute toxicity, Rota Rod and Grip Strength Tests were also performed. The significant declining in immobility time as compared to control was shown in Forced swimming test as compared to tail suspension test. Considerable change was not found in open field test (OFT). EtOH extract of seeds of fenugreek represent maximum significant reduction which was 30 and 24.65%in MAO- A and B activity respectively in the rat’s whole brain as compared to control animals in Monoamine oxidase (MAO) assay. All tested doses were found ineffective in impairment of muscle coordination in Rota rod and in grip strength related to muscle relaxant property. According to experimental findings it is revealed that ethanolic extract of seeds of Trigonella foenum graecum showed antidepressant effect by inhibiting the activity of MAO-A and B.en_US
dc.language.isoenen_US
dc.publisherKarachi: Faculty of Pharmacy, University of Karachien_US
dc.subjectTrigonella foenum graecum Linnen_US
dc.subjectantidepressanten_US
dc.subjectmonoamine oxidase assayen_US
dc.subjectneurodegenerative diseasesen_US
dc.titleAntidepressant effect and categorization of Inhibitory activity of monoamine oxidase type A and B of ethanolic extract of seeds of Trigonella foenum graecum Linnen_US
dc.typeArticleen_US
Appears in Collections:Issue No.5 (Special)

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