Comparison of the use of different analgesics in the course of anesthesia care based on pharmacoeconomics

Abstract

Narcotic analgesics play an important role in the treatment of pain. If the drug is not standardized, it is easy to cause tolerance and addiction, so scientific management and rational application is very important. In this article, we analyzed the use of narcotic analgesics in a tertiary hospital in 2015-2017. The results showed that the top 3 drugs in DDDs (defined daily doses) were fentanyl transdermal patch (4.2 mg), fentanyl transdermal patch (8.4 mg) and morphine sulfate sustained-release tablets (30 mg). Because of its strong analgesic activity and dosage form, fentanyl has become one of the first choices for severe and moderate pain in clinical practice. Morphine sulfate sustained-release tablets (30 mg) DDDs ranked third in 2015-2017, and the B/A value was 1.75. At the same time, morphine sulfate sustained-release tablets’ DDDs declined in 2017 because of the analgesic advantage of bucinnazine hydrochloride injection in emergency treatment. The dosage of pethidine hydrochloride injection is declining year by year, because its analgesic action time is very short and easy to be addicted to, and the long-term application of its metabolite, normethidine, will accumulate in the body, causing neurotoxic symptoms. The price of oxycodone hydrochloride prolonged-release tablets is relatively high, which limits its use to a certain extent. Therefore, recommend rational use of narcotic analgesics in hospitals.