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http://142.54.178.187:9060/xmlui/handle/123456789/16313| Title: | Synthesis and characterization of amino acid conjugates of oleanolic acid and their in vitro cytotoxic effect on HCC cell lines |
| Authors: | Muhammad Ayaz Mustufa Imran Ali Hashmi Shahbaz Manzoor Aamir Ahmed Viqar-ud-din Ahmed Afshan Aslam Cigdem Ozen Naim ul Hasan Naqvi Mehmet Ozturk Firdous Imran Ali |
| Keywords: | Oleanolic acid amino acid HCC cell lines amides Periploca aphylla |
| Issue Date: | 13-Sep-2014 |
| Publisher: | Karachi: Faculty of Pharmacy, University of Karachi |
| Citation: | Mustufa, M. A., Hashmi, I. A., Manzoor, S., Ahmed, A., Ahmed, V., Aslam, A., ... & Ali, F. I. (2014). Synthesis and characterization of amino acid conjugates of oleanolic acid and their in vitro cytotoxic effect on HCC cell lines. Pakistan Journal of Pharmaceutical Sciences, 27(5), 1491-1496. |
| Abstract: | Oleanolic acid (3β-hydroxy-olean-12-en-28-oic acid; OA-01), a pentacyclic triterpene, exhibit a wide range of pharmacological ad biological activities. We have isolated oleanolic acid from methanolic extract of Periploca aphylla,collected from surroundings of Karachi in the month of February. Furthermore, four known and two new C-28 amino acid conjugates of oleanolic acid were prepared to explore potential of these compounds on HCCs and one breast cancer cell line. Cytotoxic effects revealed that as compare to parent compound (OA-01), two derivatives OA-04 (p<0.0001) and OA-06 (p<0.01) showed significantly increased /higher inhibition rates. |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/16313 |
| ISSN: | 1011-601X |
| Appears in Collections: | Issue No.5 (Special) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| SP-Paper-13.htm | 143 B | HTML | View/Open |
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