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Please use this identifier to cite or link to this item: http://142.54.178.187:9060/xmlui/handle/123456789/16335
Title: Effect of Punica granatum, Citrus limon and their combinations on the plasma Gonadotropins in female rabbits
Authors: Azra Riaz
Khan, Rafeeq Alam
Neelam Mallick
Keywords: Citrus limon
Follicle stimulating hormone
Luteinizing hormone
Punica granatum
Testosterone
Issue Date: 8-May-2018
Publisher: Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi
Citation: Riaz, A., Khan, R. A., & Mallick, N. (2018). Effect of Punica granatum, Citrus limon and their combinations on the plasma Gonadotropins in female rabbits. Pakistan Journal of Pharmaceutical Sciences, 31(3).
Abstract: Fruits produce revitalizing effects, hence the impact of Punica granatum, Citrus limon and their combinations have been investigated on the plasma levels of gonadotropin, testosterone and sexual development capacity in female rabbits. Ninety female rabbits were randomly assigned into nine groups, each comprising of ten animals. One group was given saline and designated as control. Three groups were given P. granatum 2mL /kg, 5mL/kg, 8mL/kg, other three groups received C. limon 0.2mL/kg, 0.4mL/kg, 0.6mL/kg respectively, remaining groups received C. limon and P. granatum in combination i.e. 0.4mL/kg C. limon + 5mL/kg P. granatum and 0.2mL/kg C. limon + 8mL/kg P. granatum. Juices were administered once daily by mouth from day 0 of pups delivered to postnatal day15. Blood samples were gathered from ear vein at day11 and day15. There was significant increase in follicle stimulating hormone by P. granatum at 5 and 8mL/kg on day 11 and 15, by C. limon at 0.4 and 0.6mL/kg on day11, 0.4mL/kg at day15, by combination doses of C. limon and P. granatum 0.4 +5mL/kg at day 11, 0.4+5 mL/kg and 0.2 + 8mL/kg at day15. There was also significant increase in luteinizing hormone by P. granatum at 2, 5 and 8mL/kg and by C. limon 0.4mL/kg at day11. There was highly significant increase on day 11 in LH at combination doses of C. limon and P. granatum 0.4 + 5mL/kg. There was significant increase in testosterone level by P. granatum at 2, 5 and 8mL/kg on day 11 and 5mL/kg on day15 and highly significant increase at 2 and 8mL/kg. C. limon caused significant increase in testosterone at 0.4 mL/kg on day11, 0.2 and 0.6mL/kg on day 15 and highly significant increase at 0.4mL/kg on day15. Whereas combinations doses of C. limon and P. granatum at 0.4+5mL/kg caused highly significant increase in testosterone level as compare to control. Results of present study revealed increase in plasma gonadotropin and testosterone levels showing increase in sexual capacity of female rabbits which could be mainly accounted for high vitamin C and flavonoids contents of these juices.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/16335
ISSN: 1011-601X
Appears in Collections:Issue 03

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