Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/16337
Title: Assessment of potential interaction between simvastatin and clarithromycin in healthy adult male subjects
Authors: Zainab Kaleem
Khan, Junaid Ali
Zahid Mushtaq
Sidra Altaf
Ijaz Javed
Keywords: Simvastatin
plasma
plasma
clarithromycin
HPLC
pharmacokinetic interaction
Issue Date: 10-May-2018
Publisher: Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi
Citation: Kaleem, Z., Khan, J. A., Mushtaq, Z., Altaf, S., & Javed, I. (2018). Assessment of potential interaction between simvastatin and clarithromycin in healthy adult male subjects. Pakistan Journal of Pharmaceutical Sciences, 31(3), 801-807.
Abstract: Cardiac patients with weak immune system are susceptible to bacterial infections. Their prescriptions frequently contain simvastatin and clarithromycin together. The objective of present project was to assess the potential interaction between simvastatin and clarithromycin by evaluating the clarithromycin effects on the pharmacokinetics of simvastatin in healthy adult male subjects. The study design comprised of two phases, used at interval of one week. In first phase simvastatin 20 mg alone was administered to each volunteer. In second phase, co-administration of simvastatin 20 mg with clarithromycin 250 mg was made under similar specified conditions. Blood samples were collected at specified time intervals. Simvastatin plasma concentrations were analyzed through High Performance Liquid Chromatography with UV detector at 238 nm wavelength. Using one compartment open model, MW/PHARM version 3.02 software program was used by F. Rombut for pharmacokinetic parameters calculation. Clarithromycin co-treatment resulted in 2.3 fold increase in maximum plasma concentration Cmax (from 2.47±0.34 ng.mL-1 to 5.66±1.18 ng.mL-1; p<0.05) and 3.9 fold increase in area under time versus concentration curve from 0 to 10 hours AUC0-10 (from 15.10±3.73 ng.hr.mL-1 to 58.49±15.73 ng.hr.mL-1; p<0.05) of simvastatin. These results suggest that co-prescription of simvastatin and clarithromycin should be avoided to minimize the adverse events resulting from high simvastatin concentration, without sacrificing therapeutic worth of simvastatin.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/16337
ISSN: 1011-601X
Appears in Collections:Issue 03

Files in This Item:
File Description SizeFormat 
Paper-10.htm132 BHTMLView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.