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Title: | Multidrug resistance reversal activity of extract and a rare dimeric naphthoquinone from Diospyros lotus |
Authors: | Abdur Rauf Usama Shaheen Muslim Raza Ghias Uddin Taibi Ben Hadda Yahia Nasser Mabkhot Noor Jehan Bashir Ahmad Saleem Raza Molnar, Joseph Csonka, Ákos Szabó, Diána |
Keywords: | Diospyros lotus Di-naphthodiospyrol R anticancer molecular docking |
Issue Date: | 13-May-2018 |
Publisher: | Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi |
Citation: | Rauf, A., Shaheen, U., Raza, M., Uddin, G., Hadda, T. B., Mabkhot, Y. N., ... & Szabó, D. (2018). Multidrug resistance reversal activity of extract and a rare dimeric naphthoquinone from Diospyros lotus. Pakistan Journal of Pharmaceutical Sciences, 31(3). |
Abstract: | A dimeric naphthoquinone namely dihydrodyspyrole R (1) was purified once more from Diospyros lotus. Dihydrodyspyrole R and chloroform fractions were evaluated for their effects on the reversion of multidrug resistance (MDR). The compounds (1) and extract exhibited promising MDR reversing effect in a dose-dependent manner against mouse T-lymphoma cell line. Molecular docking of compound 1 revealed the correlation between in-silico with in-vitro results. The molecular docking results showed that compound 1 is bind closely where co-crystal ligand of P-gp is present. But usually, computational investigation predicts that, if a compound gives lesser score then compound will exhibit good activity. Hence, the docking scores of compound 1 are the near to the Rhodamine. It is conclude that there are certain important structural features of compound 1which are responsible for the inhibiting potency of P-gp from mice. The computational Petra/Osiris/Molinspiration (POM) analysis confirms the possibility of use of compound 1 without side effect or less toxicity risks. |
URI: | http://142.54.178.187:9060/xmlui/handle/123456789/16340 |
ISSN: | 1011-601X |
Appears in Collections: | Issue 03 |
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