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http://142.54.178.187:9060/xmlui/handle/123456789/16341| Title: | Synthesis, characterization and SAR of novel Bezimidazole derivatives as Nematicidal agents |
| Authors: | Nadia Asghar Shamim Akhtar Sabahat Naeem Ahsaan Ahmed Shaheena Faizy Muhammad Arif Zafar Saeed Saify |
| Keywords: | Benzimidazole Nematocidal activity GERD Meloidogyne incognita |
| Issue Date: | 14-May-2018 |
| Publisher: | Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi |
| Citation: | Asghar, N., Akhtar, S., Naeem, S., Ahmed, A., Faizy, S., Arif, M., & Saify, Z. S. (2018). Synthesis, characterization and SAR of novel Bezimidazole derivatives as Nematicidal agents. Pakistan Journal of Pharmaceutical Sciences, 31(3), 827-833. |
| Abstract: | Six novel analogues were prepared by reacting benzimidazole molecules (BM and CMB) propiophenone and benzoyl chlorides respectively. The structures of newly synthesized compounds were determined with the help of spectroscopic techniques. The compounds were subjected to in-vitro screening for their activity against nematodes. It was observed that the benzimidazole (BM) derivatives possessed more nematicidal activity as compared to that of cyanomethyl-benzimidazole (CMB) for Meloidogyne incognita. Among them, the propiophenone substituted benzimidazole derivative B3 was found to be the most active compound and can be further studied as lead molecule for development of anthelmintic drugs. |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/16341 |
| ISSN: | 1011-601X |
| Appears in Collections: | Issue 03 |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Paper-14.htm | 132 B | HTML | View/Open |
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