Please use this identifier to cite or link to this item:
http://142.54.178.187:9060/xmlui/handle/123456789/16357| Title: | HYPOPHAGIC AND HYPOLOCOMOTIVE EFFECTS OF METACHLORO PHENYL PIPERAZINE IN RATS TREATED WITH THEOPHYLLINE AND CAFFEINE |
| Authors: | NAUSHEEN ALAM HALEEM, DARAKSHAN JABEEN RAHILA NAJAM SYEDA HAIDER AHMED, SHAHIDA PERVEEN |
| Keywords: | Anxiety anorexia, m-CPP caffeine, theophylline |
| Issue Date: | 20-Jul-2011 |
| Publisher: | Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. |
| Citation: | Alam, N., Haleem, D. J., Najam, R., Haider, S., & Ahmed, S. P. (2011). Hypophagic and hypolocomotive effects of metachloro phenyl piperazine in rats treated with theophylline and caffeine. Pak J Pharm Sci, 24(3), 251-254. |
| Abstract: | Long term intake of coffee is known to produce anxiety and suppression of appetite. 5- hydroxytryptamine (5- HT) acting via 5-HT-2C receptors elicits anorexia and anxiety. The present study is design to monitor metachloro phenyl piperazine (m-CPP) at a dose of 3mg/ml/kg, induces hypophagia and hypolocomotion in rats taking a solution of caffeine (a component of coffee and tea) or theophylline (a component of tea) as a sole source of water. We found that hypophagic and hypolocomotive effects of m-CPP were attenuated in theophylline but not in caffeine treated animals suggesting that long term intake of theophylline may attenuate anorexiogenic and anxiogenic effects of 5-HT. A possible role of 5-HT-2C receptors in the modulation of anxiety and appetite in people drinking coffee or tea discussed. |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/16357 |
| ISSN: | 1011-601X |
| Appears in Collections: | Issue 03 |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Paper-2.htm | 142 B | HTML | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.