Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/16370
Title: NEUROPROTECTIVE EFFECT OF VITAMIN C AGAINST PTZ INDUCED APOPTOTIC NEURODEGENERATION IN ADULT RAT BRAIN
Authors: NASEER, MUHAMMAD IMRAN
IKRAM ULLAH
NAJEEB ULLAH
LEE, HAE YOUNG
CHEON, EUN WOO
JONGIL CHUNG
KIM, MYEONG OK
Keywords: PTZ
neurodegeneration
vitamin C
adult rat brain
Issue Date: 20-Jul-2011
Publisher: Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi.
Citation: Naseer, M. I., Ullah, I., Ullah, N., Lee, H. Y., Cheon, E. W., Chung, J., & Kim, M. O. (2011). Neuroprotective effect of vitamin C against PTZ induced apoptotic neurodegeneration in adult rat brain. Pakistan journal of pharmaceutical sciences, 24(3).
Abstract: The present study was designed to observe the effect of PTZ on expression of caspsae-3, and to evaluate the neuroprotective role of vitamin C (vit-C) against PTZ-induced apoptotic neurodegeneration in adult rat brain. We observed that administration of a single conclusive dose of pentylenetetrazol (PTZ 50mg/kg) in adults rats induced epileptic seizure and increased activation of caspase-3 and caused neuronal death. Further, rats were injected with vit-C (250 mg/kg) 30 min before PTZ injection. The protective effect of vit-C against PTZinduced apoptotic neurodegeneration in adult rat brain was observed using Western blot analysis and Nissl staining. The results showed that conclusive dose of PTZ-induced seizure, increased expression of caspase-3 and neuronal apoptosis in adult rat brain. Whereas, the pretreatment of vit-C along with PTZ showed significantly decreased expression of caspase-3 as compare to control group. Finally, our results indicated that vit-C can prevent some of the deleterious effect of seizure and neuronal degeneration induced by PTZ in adult rat brain.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/16370
ISSN: 1011-601X
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