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Title: | NEUROPROTECTIVE EFFECT OF VITAMIN C AGAINST PTZ INDUCED APOPTOTIC NEURODEGENERATION IN ADULT RAT BRAIN |
Authors: | NASEER, MUHAMMAD IMRAN IKRAM ULLAH NAJEEB ULLAH LEE, HAE YOUNG CHEON, EUN WOO JONGIL CHUNG KIM, MYEONG OK |
Keywords: | PTZ neurodegeneration vitamin C adult rat brain |
Issue Date: | 20-Jul-2011 |
Publisher: | Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. |
Citation: | Naseer, M. I., Ullah, I., Ullah, N., Lee, H. Y., Cheon, E. W., Chung, J., & Kim, M. O. (2011). Neuroprotective effect of vitamin C against PTZ induced apoptotic neurodegeneration in adult rat brain. Pakistan journal of pharmaceutical sciences, 24(3). |
Abstract: | The present study was designed to observe the effect of PTZ on expression of caspsae-3, and to evaluate the neuroprotective role of vitamin C (vit-C) against PTZ-induced apoptotic neurodegeneration in adult rat brain. We observed that administration of a single conclusive dose of pentylenetetrazol (PTZ 50mg/kg) in adults rats induced epileptic seizure and increased activation of caspase-3 and caused neuronal death. Further, rats were injected with vit-C (250 mg/kg) 30 min before PTZ injection. The protective effect of vit-C against PTZinduced apoptotic neurodegeneration in adult rat brain was observed using Western blot analysis and Nissl staining. The results showed that conclusive dose of PTZ-induced seizure, increased expression of caspase-3 and neuronal apoptosis in adult rat brain. Whereas, the pretreatment of vit-C along with PTZ showed significantly decreased expression of caspase-3 as compare to control group. Finally, our results indicated that vit-C can prevent some of the deleterious effect of seizure and neuronal degeneration induced by PTZ in adult rat brain. |
URI: | http://142.54.178.187:9060/xmlui/handle/123456789/16370 |
ISSN: | 1011-601X |
Appears in Collections: | Issue 03 |
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