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Title: | Evaluation of carrier added and no carrier added 90Y-EDTMP as bone seeking therapeutic radiopharmaceutical |
Authors: | Muhammad Khalid Tanveer Hussain Bokhari Mushtaq Ahmad Haq Nawaz Bhatti Munawar Iqbal Abdul Ghaffar Muhammad Imran Qadir |
Keywords: | Carrier-added Yttrium-90 No-carrier-added Yttrium-90 Strontium-90/Yttrium-90 generator EDTMP Biodistribution in rats |
Issue Date: | 10-Jul-2014 |
Publisher: | Karachi: Faculty of Pharmacy, University of Karachi |
Citation: | Khalid, M., Bokhari, T. H., Ahmad, M., Bhatti, H. N., Iqbal, M., Ghaffar, A., & Qadir, M. I. (2014). Evaluation of carrier added and no carrier added 90 Y-EDTMP as bone seeking therapeutic radiopharmaceutical. Pakistan Journal of Pharmaceutical Sciences, 27(4). |
Abstract: | The optimum conditions to label ethylenediaminetetramethylene phosphonate (EDTMP) compound with 90y as a potential candidate for bone metastases therapy were investigated. Yttrium-90 is a pure β-emitter and can be obtained by 89y (n,γ) 90y nuclear reaction in a reactor or from an in-house generator system (90sr→90y). The preparation of 90Y-EDTMPis described using 90y, which was obtained from neutron radiation of y2o3 as well as from a laboratory scale organic resin-based 90sr→90y generator. Because of the adiolabeling yield of 90Y-EDTMP on ligand/metal molar ratio, incubation time and ph was evaluated. Under optimum parameters, the radiolabeling yields of 90Y-EDTMPwere <95% for no-carrier-added as well as carrier-added 90y. The biodistribution of no-carrier-added and carrier-added 90YEDTMPcomplexes in rats was identical. The results indicate that 90y (carrier-added)-edtmp is also an effective bone pain palliation agent because of its rapid blood clearance, greater uptake in bones and little absorption in soft tissues. |
URI: | http://142.54.178.187:9060/xmlui/handle/123456789/16372 |
ISSN: | 1011-601X |
Appears in Collections: | Issue No.4 |
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File | Description | Size | Format | |
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Paper-10.htm | 132 B | HTML | View/Open |
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