Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/16372
Title: Evaluation of carrier added and no carrier added 90Y-EDTMP as bone seeking therapeutic radiopharmaceutical
Authors: Muhammad Khalid
Tanveer Hussain Bokhari
Mushtaq Ahmad
Haq Nawaz Bhatti
Munawar Iqbal
Abdul Ghaffar
Muhammad Imran Qadir
Keywords: Carrier-added Yttrium-90
No-carrier-added Yttrium-90
Strontium-90/Yttrium-90 generator
EDTMP
Biodistribution in rats
Issue Date: 10-Jul-2014
Publisher: Karachi: Faculty of Pharmacy, University of Karachi
Citation: Khalid, M., Bokhari, T. H., Ahmad, M., Bhatti, H. N., Iqbal, M., Ghaffar, A., & Qadir, M. I. (2014). Evaluation of carrier added and no carrier added 90 Y-EDTMP as bone seeking therapeutic radiopharmaceutical. Pakistan Journal of Pharmaceutical Sciences, 27(4).
Abstract: The optimum conditions to label ethylenediaminetetramethylene phosphonate (EDTMP) compound with 90y as a potential candidate for bone metastases therapy were investigated. Yttrium-90 is a pure β-emitter and can be obtained by 89y (n,γ) 90y nuclear reaction in a reactor or from an in-house generator system (90sr→90y). The preparation of 90Y-EDTMPis described using 90y, which was obtained from neutron radiation of y2o3 as well as from a laboratory scale organic resin-based 90sr→90y generator. Because of the adiolabeling yield of 90Y-EDTMP on ligand/metal molar ratio, incubation time and ph was evaluated. Under optimum parameters, the radiolabeling yields of 90Y-EDTMPwere <95% for no-carrier-added as well as carrier-added 90y. The biodistribution of no-carrier-added and carrier-added 90YEDTMPcomplexes in rats was identical. The results indicate that 90y (carrier-added)-edtmp is also an effective bone pain palliation agent because of its rapid blood clearance, greater uptake in bones and little absorption in soft tissues.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/16372
ISSN: 1011-601X
Appears in Collections:Issue No.4

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