Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/16393
Title: Determination of pKa values of new phenacyl-piperidine derivatives by potentiometric titration method in aqueous medium at room temperature (25±0.5o C)
Authors: Shaista Zafar
Shamim Akhtar
Talat Tariq
Noushin Mushtaq
Arfa Akram
Ahsaan Ahmed
Muhammad Arif
Sabahat Naeem
Sana Anwar
Keywords: Dissociation constant
phenacyl derivatives
CNS active agents
potentiometry
lipophilicit
pH partition theory
Issue Date: 26-Jul-2014
Publisher: Karachi: Faculty of Pharmacy, University of Karachi
Citation: Zafar, S., Akhtar, S., Tariq, T., Mushtaq, N., Akram, A., Ahmed, A., ... & Anwar, S. (2014). Determination of pKa values of new phenacyl-piperidine derivatives by potentiometric titration method in aqueous medium at room temperature (25±0.5° C). Pakistan Journal of Pharmaceutical Sciences, 27(4).
Abstract: Dissociation constant (pKa) of ten novel phenacyl derivatives of piperidine were determined by potentiometric titration method in aqueous medium at room temperature (25 ±0.5o C). The sample solutions were prepared in deionized water with ionic strength 0.01M and titrated with 0.1M NaOH solution. In addition, ∆G values were also calculated. Different prediction software programs were used to calculate pKa values too and compared to the experimentally observed pKa values. The experimental and theoretical values were found in close agreement. The results obtained in this research would help to predict the good absorption of the studied compounds and can be selected as lead molecules for the synthesis of CNS active agents because of their lipophilic nature especially compound VII.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/16393
ISSN: 1011-601X
Appears in Collections:Issue No.4

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