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DC Field | Value | Language |
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dc.contributor.author | Sabrin Ragab Mohamed Ibrahim | - |
dc.contributor.author | Gamal Abdallah Mohamed | - |
dc.contributor.author | Maan Talaat Abdullah Khayat | - |
dc.contributor.author | Mohamed Fathalla Zayed | - |
dc.contributor.author | El-Kholy, Amal Abd-Elmoneim Soliman | - |
dc.date.accessioned | 2023-01-20T07:29:44Z | - |
dc.date.available | 2023-01-20T07:29:44Z | - |
dc.date.issued | 2018-07-01 | - |
dc.identifier.citation | Ibrahim, S. R. M., Mohamed, G. A., Khayat, M. T. A., Zayed, M. F., & El-Kholy, A. A. E. S. (2018). Anti-inflammatory terpenoids from Cyperus rotundus rhizomes. Pakistan journal of pharmaceutical sciences, 31. | en_US |
dc.identifier.issn | 1011-601X | - |
dc.identifier.uri | http://142.54.178.187:9060/xmlui/handle/123456789/16395 | - |
dc.description.abstract | Phytochemical investigation of the methanolic extract of Cyperus rotundus L. (Cyperaceae) rhizomes afforded a new norterpenoid with an unprecedented carbon skeleton, namely cyperalin A (1) and sugetriol triacetate (2). Their structures were identified by using advanced spectroscopic technique such as UV, IR, 1D (1 H and 13C), 2D (1 H-1 H COSY, HSQC, HMBC, and NOESY) NMR, and HRESIMS as well as comparison with literature data. The isolated compounds were evaluated for their anti-inflammatory activity. Compound 1 displayed the highest inhibitory activity of PGE2, COX-2, and LOX-5 with IC50s 0.22, 1.03, and 1.37 µM, respectively compared to indomethacin (IC50s 0.15, 0.69, and 0.81 µM, respectively). Moreover, 2 demonstrated significant activity with IC50s 0.57 (PGE2), 1.74 (COX-2) and 2.03 (LOX-5) µM. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi | en_US |
dc.subject | Cyperus rotundus | en_US |
dc.subject | cyperaceae | en_US |
dc.subject | terpenoids | en_US |
dc.subject | cyperalin a | en_US |
dc.subject | anti-inflammatory | en_US |
dc.title | Anti-inflammatory terpenoids from Cyperus rotundus rhizomes | en_US |
dc.type | Article | en_US |
Appears in Collections: | Issue No.4 (Supplementary) |
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File | Description | Size | Format | |
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1-SUP-816.htm | 147 B | HTML | View/Open |
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