Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/16395
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dc.contributor.authorSabrin Ragab Mohamed Ibrahim-
dc.contributor.authorGamal Abdallah Mohamed-
dc.contributor.authorMaan Talaat Abdullah Khayat-
dc.contributor.authorMohamed Fathalla Zayed-
dc.contributor.authorEl-Kholy, Amal Abd-Elmoneim Soliman-
dc.date.accessioned2023-01-20T07:29:44Z-
dc.date.available2023-01-20T07:29:44Z-
dc.date.issued2018-07-01-
dc.identifier.citationIbrahim, S. R. M., Mohamed, G. A., Khayat, M. T. A., Zayed, M. F., & El-Kholy, A. A. E. S. (2018). Anti-inflammatory terpenoids from Cyperus rotundus rhizomes. Pakistan journal of pharmaceutical sciences, 31.en_US
dc.identifier.issn1011-601X-
dc.identifier.urihttp://142.54.178.187:9060/xmlui/handle/123456789/16395-
dc.description.abstractPhytochemical investigation of the methanolic extract of Cyperus rotundus L. (Cyperaceae) rhizomes afforded a new norterpenoid with an unprecedented carbon skeleton, namely cyperalin A (1) and sugetriol triacetate (2). Their structures were identified by using advanced spectroscopic technique such as UV, IR, 1D (1 H and 13C), 2D (1 H-1 H COSY, HSQC, HMBC, and NOESY) NMR, and HRESIMS as well as comparison with literature data. The isolated compounds were evaluated for their anti-inflammatory activity. Compound 1 displayed the highest inhibitory activity of PGE2, COX-2, and LOX-5 with IC50s 0.22, 1.03, and 1.37 µM, respectively compared to indomethacin (IC50s 0.15, 0.69, and 0.81 µM, respectively). Moreover, 2 demonstrated significant activity with IC50s 0.57 (PGE2), 1.74 (COX-2) and 2.03 (LOX-5) µM.en_US
dc.language.isoenen_US
dc.publisherKarachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachien_US
dc.subjectCyperus rotundusen_US
dc.subjectcyperaceaeen_US
dc.subjectterpenoidsen_US
dc.subjectcyperalin aen_US
dc.subjectanti-inflammatoryen_US
dc.titleAnti-inflammatory terpenoids from Cyperus rotundus rhizomesen_US
dc.typeArticleen_US
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