Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/16425
Title: INTESTINAL PERMEABILITY STUDIES OF SULPIRIDE INCORPORATED INTO SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS)
Authors: CHITNENI, MALLIKARJUN
KOK KHIANG PEH
YUSRIDA DARWIS
MUTHANNA ABDULKARIM
GHASSAN ZUHAIR ABDULLAH
QURESHI, MOHAMMED JAVED
Keywords: Sulpiride
single-pass intestinal perfusion technique
SMEDDS
micellar solution
effective permeability coefficient
Issue Date: 4-Apr-2011
Publisher: Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi
Citation: Chitneni, M., Peh, K. K., Darwis, D., Abdulkarim, M., Abdullah, G. Z., & Qureshi, M. J. (2011). Intestinal permeability studies of sulpiride incorporated into self-microemulsifying drug delivery system (SMEDDS). Pak J Pharm Sci, 24(2), 113-121.
Abstract: The objective of the present study was to determine the intestinal absorption of sulpiride incorporated into SMEDDS by means of single-pass intestinal perfusion method (SPIP) in rat and to compare the effective permeability coefficient obtained with that of drug solution and micellar solution. The prepared SMEDDS and micelles formulations were investigated for droplets size. SPIP experiment was performed using the three formulations in three of the secluded regions of the small intestine (duodenum, jejunum, and ileum). The amount of the drug in the samples was estimated by HPLC and the effective permeability coefficients in rats were calculated. The human intestinal permeability was predicted based on rat effective permeability coefficient value. The dilution stability of the formulations was also determined. The average droplet size of SMEDDS and micelles was 9.27 nm and 7.20 nm respectively. The effective permeability coefficient of sulpiride was appreciably lower in the ileum weighed against jejunum and duodenum when administered as a solution (p<0.05). The estimated human absorption of sulpiride for the SMEDDS dilutions was superior to that from solution (p<0.05) and similar to micellar solution. The micellar dilutions were unstable whereas the SMEDDS dilutions were stable. Based on the above results, SMEDDS can be a potential candidate for improving the peroral absorption of the sulpiride.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/16425
ISSN: 1011-601X
Appears in Collections:Issue 02

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