Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/16439
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dc.contributor.authorSHEFAAT ULLAH SHAH-
dc.contributor.authorKIFAYAT ULLAH SHAH-
dc.contributor.authorASIMUR REHMAN-
dc.contributor.authorKHAN, GUL MAJID-
dc.date.accessioned2023-01-20T07:42:30Z-
dc.date.available2023-01-20T07:42:30Z-
dc.date.issued2011-04-14-
dc.identifier.citationShah, S. U., Shah, K. U., Rehman, A., & Khan, G. M. (2011). Investigating the in vitro drug release kinetics from controlled release diclofenac potassium-ethocel matrix tablets and the influence of co-excipients on drug release patterns. Pak J Pharm Sci, 24(2), 183-92.en_US
dc.identifier.issn1011-601X-
dc.identifier.urihttp://142.54.178.187:9060/xmlui/handle/123456789/16439-
dc.description.abstractThe objective of the study was to formulate and evaluate controlled release polymeric tablets of Diclofenac Potassium for the release rate, release patterns and the mechanism involved in the release process of the drug. Formulations with different types and grades of Ethyl Cellulose Ether derivatives in several drug-to-polymer ratios (D:P) were compressed into tablets using the direct compression method. In vitro drug release studies were performed in phosphate buffer (pH 7.4) as dissolution medium by using USP Method-1 (Rotating Basket Method). Similarity factor f2 and dissimilarity factor f1 were applied for checking the similarities and dissimilarities of the release profiles of different formulations. For the determination of the release mechanism and drug release kinetics various mathematical / kinetic models were employed. It was found that all of the Ethocel polymers could significantly slow down the drug release rate with Ethocel FP polymers being the most efficient, especially at D:P ratios of 10:03 which lead towards the achievement of zero or near zero order release kinetics.en_US
dc.language.isoenen_US
dc.publisherKarachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachien_US
dc.subjectDiclofenac Potassiumen_US
dc.subjectEthocel Standard Premiumen_US
dc.subjectEthocel Standard FP Premiumen_US
dc.subjectcontrolled release tabletsen_US
dc.subjectrelease pattern and kineticsen_US
dc.subjectnfluence of co-excipientsen_US
dc.titleINVESTIGATING THE IN VITRO DRUG RELEASE KINETICS FROM CONTROLLED RELEASE DICLOFENAC POTASSIUM-ETHOCEL MATRIX TABLETS AND THE INFLUENCE OF CO-EXCIPIENTS ON DRUG RELEASE PATTERNSen_US
dc.typeArticleen_US
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