ANTI DIABETIC EFFECT OF ACHYRANTHES RUBROFUSCA LEAF EXTRACTS ON ALLOXAN INDUCED DIABETIC RATS

Abstract

The aqueous and ethanolic extracts of Achyranthes rubrofuca leaves (AR) were studied for their hypoglycemic activity. Thirty animals were taken and they were divided into five groups. First group acts as control, remaining 4 groups were induced diabetics by administering alloxan (120mg/kg i.p). Second group serves as diabetes control, third group treated with Glibenclamide (5mg/kg), fourth and fifth group were given aqueous and ethanolic extracts of leaves (200mg/kg/ body weight/day/po for 28 days) to rats. The anti hyperglycemic activity by AR was compared with the group treated with the standard oral hypoglycemic agent. Treatment with aqueous and ethanolic extract of AR caused a significant change when compared to the untreated animals with respect to body weight, blood glucose level, and lipid profile. Aqueous extract showed slightly better activity than ethanolic extract but it may not be statistically significant. There is significant increases in the pancreatic enzyme like SOD, CAT and Glutathione expression when compare with the untreated group. Decreases in LPO level is observed in the group treated with extracts when compare with control groups animals. The histopathological studies also show the regenerative effect of pancreas, supported the above activities of AR leaves.