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http://142.54.178.187:9060/xmlui/handle/123456789/16449| Title: | REPORT TREATMENT OF NIGELLA SATIVA IN EXPERIMENTAL SEPSIS MODEL IN RATS |
| Authors: | ALICI, OZLEM KAVAKLI, HAVVA SAHIN KOCA, CEMILE ALTINTAS, NERIMAN DEFNE |
| Keywords: | Sepsis Nigella sativa oil endothelin superoxide dismutase malondialdehyde |
| Issue Date: | 21-Apr-2011 |
| Publisher: | Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi |
| Citation: | Alici, O., Kavakli, H. S., Koca, C., & Altintas, N. D. (2011). Treatment of Nigella sativa in experimental sepsis model in rats. Pakistan journal of pharmaceutical sciences, 24(2), 227-232. |
| Abstract: | This experimental study was designed to determine effects of Nigella sativa oil (NSO) on endothelin-1 (ET-1) level and oxidative stress parameters, superoxide dismutase (SOD) and malondialdehyde (MDA) in a rat sepsis model. Twenty four adult Wistar albino rats were divided randomly into three groups: sham group (group 1), sepsis group (group 2), sepsis group pretreated with NSO (group 3). Serum ET-1, tissue SOD and tissue MDA levels were measured in all groups. Compared to group 1, ET-1 and MDA levels were higher in group 2. ET-1 and MDA levels in NSO pretreated group 3 were lower with respect to group 2 (p<0.03, and p<0.02, respectively). Additionally, SOD levels in group 3 were found to be higher than group 2 (p<0.02). Based on our results, it can be concluded that NSO may have a positive impact on ET-1 levels and oxidative stress induced by sepsis in experimental rat models. |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/16449 |
| ISSN: | 1011-601X |
| Appears in Collections: | Issue 02 |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Paper-21.htm | 143 B | HTML | View/Open |
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