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Title: | Anti-nociceptive and anti-inflammatory activities of the extracts of Stauntonia chinensis |
Authors: | Chen Ying Wu Ning Liu Ying Gao Hao Jin, Dong Hua Bin, Su Rui Sheng, Yao Xin Li Jin |
Keywords: | Stauntonia chinensis DC Antinociceptive activity Anti-inflammatory activity PGE2 production |
Issue Date: | 20-Sep-2014 |
Publisher: | Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. |
Citation: | Ying, C., Ning, W., Ying, L., Hao, G., Hua-Jin, D., Rui-Bin, S., ... & Jin, L. (2014). Anti-nociceptive and anti-inflammatory activities of the extracts of Stauntonia chinensis. Pakistan Journal of Pharmaceutical Sciences, 27(5). |
Abstract: | The aim of this investigation was to study the anti-nociceptive and anti-inflammatory activities of Stauntonia chinensis (S. chinensis) and the possible action mechanisms of effective fractions. The anti-nociceptive and antiinflammatory activities of S. chinensis extracts, including the 60% EtOH extract (YMG), the n-BuOH extract (YMGB) and the aqueous residue (YMGW) of YMG, and the fractions from YMGB (YMGB1~YMGB7) were investigated by using the mouse acetic acid-induced writhing test and the rat formalin test. The effect of these extracts on the PGE2 production was tested as well. In the mouse acetic acid-induced writhing test and the rat formalin test, YMGW and YMGB displayed anti-nociceptive and anti-inflammatory activities, suggesting that they were the active ingredients of YMG. Among the fractions isolated from YMGB, YMGB1, YMGB3, YMGB4 and YMGB6 were the main active ingredients producing anti-nociceptive activity and YMGB3, YMGB5, YMGB6 and YMGB7 were the main active ingredients producing anti-inflammatory activity. Additionally, YMGW, YMGB and its separations reduced the production of PGE2, which might be the mechanism of them producing anti-inflammatory activity. These results demonstrated the active ingredients of S. chinensis producing anti-nociceptive and anti-inflammatory activities, which is valuable to validate the substance basis of S. chinensis’s pharmacological actions. |
URI: | http://142.54.178.187:9060/xmlui/handle/123456789/16516 |
ISSN: | 1011-601X |
Appears in Collections: | Issue No.5 |
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Paper-28.htm | 132 B | HTML | View/Open |
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