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http://142.54.178.187:9060/xmlui/handle/123456789/16535| Title: | HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF ISONIAZID, PYRAZINAMIDE AND RIFAMPICIN IN PHARMACEUTICAL PREPARATIONSHIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF ISONIAZID, PYRAZINAMIDE AND RIFAMPICIN IN PHARMACEUTICAL PREPARATIONS |
| Authors: | M.Y. KHUHAWAR F.M.A. RIND |
| Issue Date: | 7-Jul-1998 |
| Publisher: | Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi |
| Citation: | Khuhawar, M. Y., & Rind, F. M. (1998). High performance liquid chromatographic determination of isoniazid, pyrazinamide and rifampicin in pharmaceutical preparations. Pakistan journal of pharmaceutical sciences, 11(2), 49-54. |
| Abstract: | Isoniazid (IS) individually or in the presence of pyrazinamide and rifampicin has been determined by high performance liquid chromatography (HPLC) after derivatization with 6-methyl-2-pyridinecarboxaldehyde. Pyrazinamide and rifampicin separate completely from isoniazid derivative and are determined imultaneously. The chromatography is carried out from YMC-ODS column with elution with methanol: water: isopropanol: acetonitrile: sodium acetate (1 mM) 51:42:3:2:2: v/v/v/v/v/) with flow rate 1.7 ml/min and UV detection at 333 nm. The method is applied for the analysis of Isoniazid B.P Rambuzid and Myrene-p tablets. |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/16535 |
| ISSN: | 1011-601X |
| Appears in Collections: | Issue 2 |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Paper-7.htm | 142 B | HTML | View/Open |
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