HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF ISONIAZID, PYRAZINAMIDE AND RIFAMPICIN IN PHARMACEUTICAL PREPARATIONSHIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF ISONIAZID, PYRAZINAMIDE AND RIFAMPICIN IN PHARMACEUTICAL PREPARATIONS

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Title:	HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF ISONIAZID, PYRAZINAMIDE AND RIFAMPICIN IN PHARMACEUTICAL PREPARATIONSHIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF ISONIAZID, PYRAZINAMIDE AND RIFAMPICIN IN PHARMACEUTICAL PREPARATIONS
Authors:	M.Y. KHUHAWAR F.M.A. RIND
Issue Date:	7-Jul-1998
Publisher:	Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi
Citation:	Khuhawar, M. Y., & Rind, F. M. (1998). High performance liquid chromatographic determination of isoniazid, pyrazinamide and rifampicin in pharmaceutical preparations. Pakistan journal of pharmaceutical sciences, 11(2), 49-54.
Abstract:	Isoniazid (IS) individually or in the presence of pyrazinamide and rifampicin has been determined by high performance liquid chromatography (HPLC) after derivatization with 6-methyl-2-pyridinecarboxaldehyde. Pyrazinamide and rifampicin separate completely from isoniazid derivative and are determined imultaneously. The chromatography is carried out from YMC-ODS column with elution with methanol: water: isopropanol: acetonitrile: sodium acetate (1 mM) 51:42:3:2:2: v/v/v/v/v/) with flow rate 1.7 ml/min and UV detection at 333 nm. The method is applied for the analysis of Isoniazid B.P Rambuzid and Myrene-p tablets.
URI:	http://142.54.178.187:9060/xmlui/handle/123456789/16535
ISSN:	1011-601X
Appears in Collections:	Issue 2

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