DISPOSITION KINETICS AND DOSAGE OF KANAMYCIN IN BUFFALO HEIFERS

Abstract

Kanamycin is an extensively used antibiotic in veterinary practice. Therefore, its disposition kinetics and dosage were investigated in healthy buffalo heifers following a single intramuscular dose of 5 mg/kg body weight. The blood samples collected at proposed time intervals were analyzed for kanamycin concentration by a microbiological assay. Two-compartment model kinetic analysis revealed that the elimination half life (Ph 11) was 4.58 ± 0.75 hours (Mean ± SD). The mean ± SD value of apparent volume of distribution (Vd) was 0.63 ± 0.10 L/kg. Total body clearance (TBC) was 1.67 ± 0.16 ml/min. kg (Mean ± SD). To maintain minimum inhibitory concentration (MIC) of 1.5 pg/ml, the optimum priming and maintenance doses of 6.45 and 5.50 mg/kg body weight, respectively, to be repeated with the dosing interval of 12 hours have been suggested.