Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/1893
Title: Apoptotic effect of α-Fe2O3 and SiO2 nanoparticles in human rhabdomyosarcoma cell line
Authors: Fatima, Mahvish
Atif, M
Fakhar-e-Alam, Muhammad
Zaidi, S S Z
Suleman, R
Shakoor, Muhammad Nadeem
Afzal, Muhammad
Waseem, Muhammad
Aziz, Muhammad Hammad
Keywords: Natural Science
Apoptotic effect
α-Fe2O3
SiO2
nanoparticles
human rhabdomyosarcoma cell line
Issue Date: 1-Jan-2014
Publisher: Institute of Physics
Abstract: Nanotechnology provides the opportunity for the development of new materials in the nanometer size range, with many potential applications in biological sciences and clinical medicine. It has been reported that RD (muscle cancer cell line) is the most common soft tissue sarcoma in children originating from immature cells, comprising 2.9% of all malignancies in patients younger than 20 years old, with 350 cases diagnosed annually in the United States. Soft tissue is the most common target organ for nanoparticles after they gain significant entry into the target site through any of the possible routes. RD cell lines have been used as an experimental biological model in this article. A suitable environment was provided until 75% of RD cell confluence was reached. Prior to determination of toxicity of hematite (α-Fe2O3) and SiO2 nanoparticles, the sizes and shapes were confirmed using scanning electron microscopy (SEM), and the sizes were about 66 and 250 nm respectively. Moreover, 10–80 μg ml−1 of α-Fe2O3 and SiO2 nanoparticles dispersed in solution were labeled for each row of 96 well plates. The present study evaluates the suppression factor of the said particles, which leads to cell killing phenomena. After successful measurements in the above mentioned experiment, the author will be able to give the actual cause of cell killing effects. The given study has provided valuable insights into a feasible mechanism of apoptosis caused by α-Fe2O3 and SiO2 nanoparticles. An underlying promising mechanism of apoptosis due to α-Fe2O3 and SiO2 nanoparticle exposure should be further investigated at the in vivo level.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/1893
ISSN: 24 125602
Appears in Collections:Journals

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