CHANGES IN THE SERUM IRON, AMINOTRANSFERASES AND BLOOD PROFILE OF THE PRE-TREATMENT LEUKEMIA PATIENTS

Abstract

The objective of the current study was to investigate the changes in the serum iron levels, transaminases activity and demonstrate the changes in the complete blood profile of pre-treatment leukemia patients. 2m1 of blood samples from the patients and Control subjects were collected in EDTA containing vacutainers to study the blood profile by an automated hematology analyzer and 6m1 of the blood was transferred to vacutainers (without any clotting factor), left at room temperature for lh, centrifuged at 4000 rpm for 10 minutes and serum was isolated and stored at -20°C until further use. A significant increase in the WBC count (P<0.0001), lymphocytes percentage (P<0.0001), ALT (P=0.0076) and AST activity (P=0.0381) was found. The platelets were significantly decreased in the leukemia patients (P<0.0001). Serum iron levels were decreased in the early (P=0.2380) and older age groups (P=0.0027) and other groups had an increased serum iron levels. From these findings we can conclude that different hematological parameters changes significantly in the pre-treatment leukemia patients including the WBCs, platelets, serum iron, and amino transferases in different age groups which could be of medical importance for therapeutic purpose.