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http://142.54.178.187:9060/xmlui/handle/123456789/19175| Title: | Synthesis and Reactions of 4, 6—Diaryl— 2,3,4,5-Tetrahydropyridazin-3-ones |
| Authors: | M.A.Sayed A.A.El-Khamry A.Y.Soliman A.A.Afify E.A.Kassab |
| Issue Date: | 20-Sep-1988 |
| Publisher: | HEJ Research Institute of Chemistry, University of Karachi, Karachi. |
| Citation: | Sayed, G. H., Shiba, S. A., Radwan, A., Mohamed, S. M., & Khalil, M. (1992). Synthesis and reactions of some 6‐aryl and 2, 6‐diaryl‐4‐(4′‐antipyrinyl)‐2, 3, 4, 5‐tetrahydropyridazin‐3‐ones and screening for their antibacterial activities. Chinese Journal of Chemistry, 10(5), 475-480. |
| Abstract: | The hitherto unknown 4,6-diaryl -2,3,4,5-tetrahydro-pyridazi n-3-ones (Il)a-e were synthesised from the a-aryl , B-aroylpropionic acids (I)a-e either by their reaction with hydrazine hydrate or by their conversion to a,y-diaryl- 'Ltenol treatment of the latter with hydrazine hydrate. ( I l) afforded 3-chloropyridazine derivative (IV) on its reaction with POCI PCI 3' The 3-chl oropyridazine was treated either with sodium azide producing the tetrazolopyridazine derivative (V) or with acylhydrazines to give the triazolopyridazine derivatives (Vl)a-c. 3-Acy1pyridazines (Vll)a & b were obtained on treataent of (Il ) with acetyl chloride. (Il)a was converted¯to its corresponding thione (VI Il), also reacted with benzyl amine giving 3-N-benzy1pyridaz ine (l X). (Il)a was dehydrogenated to the corresponding dihydropyri dazinone |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/19175 |
| ISSN: | 0253-5106 |
| Appears in Collections: | Issue 03 |
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| ViewByVolume.aspx?v=144&i=VOLUME%2010,%20NO3,%20SEPT%201988.htm | 150 B | HTML | View/Open |
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