SYNTHESIS, SPECTRAL INVESTIGATION (1H, 13C) OF NEW (N, O AND S BASED) SCHIFF BASES AND EVALUATION OF THEIR ANTIMICROBIAL ACTIVITIES

Abstract

Three new series of biologically active amino substituted Schiff bases (1-12) with general formula, R1N=CHR2 (R1 = 2-amino-benzthiazole, 4-amino-salicylic acid and 4-aminophenol; R2 = benzaldehyde, 2-chloro-benzaldehyde, 4-chloro-benzaldehyde, salicylaldehyde and vanillin) were synthesized by the reaction of three different amino substituted compounds and substituted aldehydes in ethanol. The synthesized compounds were characterized by different physico-chemical techniques like, melting point, elemental analysis, multinuclear nmr (1H, 13C). The compounds were subjected for bioassay screening and showed promising antibacterial and antifungal activities using Amoxicillin and Ciprofloxacin as standard drugs.