ANTIMICROBIAL CONSTITUENTS FROM AERVA JAVANICA

Abstract

In the course of screening program we have isolated six natural products from the whole plant of Aerva javanica. Isoquercetrin (1), 5-methylmellein (2), 2-hydroxy-3-O-β -primeveroside naphthalene-1,4-dione (3), Apigenin 7-O-glucuronide (4), Kaempferol-3-O-β-D-glucopyranosyl-(1→2)-α-L-rhamnopyranoside-7-O-α-L-rhamnopyranoside (5), 7-(1? hydroxyethyl)-2-(2″-hydroxyethyl)-3,4-dihydrobenzopyran (6) were isolated for the first time from Aerva javanica. Structural evidences were made by the extensive use of chemical and spectral studies. Different crude extracts (n-hexane, chloroform, ethyl acetate, methanol and water) and the all known isolated compounds were tested for their antimicrobial activity which displayed moderate to weak inhibitory activity.