Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/19730
Title: Lead Application for the Stimulation of Fusaricidin Type Compounds by Paenibacillus polymyxa SQR-21
Authors: WASEEM RAZA
HONGSHENG WU
YANGCHUN XU
SHEN QIRONG
Issue Date: 10-Apr-2011
Publisher: Karachi: The Chemical Society Of Pakistan
Citation: WU, H., QIRONG, S., Xu, Y., & RAZA, W. (2011). Lead application for the stimulation of fusaricidin type compounds by Paenibacillus polymyxa SQR-21. Journal of the Chemical Society of Pakistan, 33(6), 193.
Abstract: Paenibacillus polymyxa strains produce fusaricidin type compounds that are active against a wide variety of Gram-positive bacteria and fungi. Growth and production of fusaricidin type antifungal compounds by P. polymyxa SQR-21 were compared in tryptone broth supplemented with three concentrations (200, 400 and 600 µM) of lead. The data revealed that the growth of P. polymyxa increased by 7-34 % and fusaricidin type compounds production increased by 15-70 % with the increase in concentration of lead ion (Pb²⁺). The increase in Pb²⁺ concentration, decreased the intracellular carbohydrate contents but increased the intracellular protein and lipid contents, however, higher levels of Pb2+ inhibited the intracellular protein and lipid contents. On the other hand, extracellular protein contents were decreased and extracellular polysaccharide contents were increased with the increase in Pb2+ contents in liquid culture. In addition, the regulatory effects of lead were also reflected by decrease of total RNA and increase of relative expression of the six module-containing nonribosomal peptide synthetase (FusA) when the lead treated experimental samples were compared with the untreated controls. The Pb²⁺ seems to be directly or indirectly correlated with the production of fusaricidin type antifungal compounds. This information will aid in developing fermentation technology for maximum antibiotic production.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/19730
ISSN: 0253-5106
Appears in Collections:Issue 02

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