Comparison of Human Serum Neopterine and CRP Levels

Abstract

Neopterine (NP), low weight molecule of 2-amino-4-hydroxy, is pterin. NP is a catabolic product of guanosine triphosphate (GTP) that is apurine nucleotide. It also is synthesized by macrophages. These cells are the most influential stimulants of NP production. The objective of this study is to investigate whether there is any correlation with the C - reactive protein (CRP) levels which has acute phase reactor of the NP levels having the presence of cell immunity. With the aim of this, NP and CRP levels are examined in the 150 serum species which were attained from Selcuk University Meram Clinical Medicine Faculty Biochemistry Laboratory and chosen. NP levels are examined by using fluorescent detector in the High Pressure Liquid Chromatography (HPLC) device and the CRP levels are examined with the method of immunoturbidimetric. By considering various CRP levels, samples (0-5, 5-9, 10-29, 30-59, 60 and up mg / l) were analyzed by grouping. When all of the results of the samples are evaluated, meaningful positive correlations has been detected between the NP and CRP levels. A distinct level of this correlation has been observed to be different in CRP groups and the highest point of NP level has been the 30-59 mg / l group in CRP. In the light of the results of this study, it has been observed that the levels of NP is generating in correlation with CRP levels but this correlation has been different than other CRP groups and it can’t be applied to all groups.