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http://142.54.178.187:9060/xmlui/handle/123456789/19860| Title: | Synthesis, Characterization and Antitumor Activities of 1,1`-Diacetylferrocene Dihydrazone Containing a Salicylaldehyde Moiety and its Complexes with Pd(II) and Pt(II) |
| Authors: | Wael Hussein Hegazy Yasair Suliman Al Faiyz |
| Keywords: | Bioinorganic chemistry Schiff base Ligands Metallocenes, Pd(II) and Pt(II) complexes biometals. |
| Issue Date: | 20-Oct-2013 |
| Publisher: | HEJ Research Institute of Chemistry, University of Karachi, Karachi. |
| Citation: | Hegazy, W. H., & Al-Faiyz, Y. S. (2013). Synthesis, Characterization and Antitumor Activities of 1, 1-Diacetylferrocene Dihydrazone Containing a Salicylaldehyde Moiety and its Complexes with Pd (II) and Pt (II). Journal of the Chemical Society of Pakistan, 35(5). |
| Abstract: | A ferrocenyl ligand was prepared from condensation of 1,1`-diacetylferrocene dihydrazone with salicylaldehyde. Ligand forms 1:1 complexes with Pd(II) and Pt(II) in good yield. Characterization of the ligand and complexes was carried out using elemental analysis, infrared, ¹H nuclear magnetic resonance and electronic absorption spectra. Anticancer activity of the prepared ligand and its complexes against human breast cancer cell line MCF-7 was determined, and the results were compared with the activity of the commonly used anticancer drug cisplatin. The results suggested that the prepared compounds possess significant antitumor activity comparable to the activity of cisplatin and may be potent anticancer agents for inclusion in modern clinical trials. |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/19860 |
| ISSN: | 0253-5106 |
| Appears in Collections: | Issue 05 |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| ViewByVolume.aspx?v=194&i=VOLUME%2035,%20NO5,%20OCT-2013.htm | 147 B | HTML | View/Open |
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