Sensitivity of Cells Towards Streptolysin S (SLS)

Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/19888

Title:	Sensitivity of Cells Towards Streptolysin S (SLS)
Authors:	BADARUDDIN A. MEMON
Issue Date:	12-Apr-2010
Publisher:	HEJ Research Institute of Chemistry, University of Karachi, Karachi.
Citation:	MEMON, B. R. A. (2010). Sensitivity of Cells Towards Streptolysin S (SIS). J. Chem. Soc. Pak, 32(2), 95.
Abstract:	Streptolysin S (SLS) produced by group A Streptococcus (GAS) is very potent membrane-damaging agent and lyses a wide variety of living cells and organelles. This study is about the comparison between the relative sensitivity of sheep red blood cells (haemolytic assay) and that of rabbit peritoneal neutrophils (chemiluminescence assay) towards the purified SLS. Purified SLS, at concentrations of between 8000 HU/ml and 256 HU/ml, when added directly to FMLP-induced rabbit PMNs, caused inhibition of the PMNs chemiluminescence response. This study concludes that on a cell basis, sheep red blood cells are 1.2x105 fold more sensitive to SLS than PMNs.
URI:	http://142.54.178.187:9060/xmlui/handle/123456789/19888
ISSN:	0253-5106
Appears in Collections:	Issue 02

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