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http://142.54.178.187:9060/xmlui/handle/123456789/19921| Title: | ANTIBACTERIAL, ANTIMALARIAL AND LEISHMANICIDAL ACTIVITIES OF CU (II) AND NICKEL (II) COMPLEXES OF DICLOFENAC SODIUM |
| Authors: | FAZAL-UR-REHMAN MUHAMMAD FARID KHAN INAM ULLAH KHAN MARWAT GUL MAJID KHAN HAROON KHAN |
| Issue Date: | 20-Aug-2010 |
| Publisher: | HEJ Research Institute of Chemistry, University of Karachi, Karachi. |
| Citation: | ur Rehman, F. (2010). Antibacterial, antimalarial and leishmanicidal activities of Cu (II) and nickel (II) complexes of diclofenac sodium. Journal of the Chemical Society of Pakistan, 32(6), 462. |
| Abstract: | Metal complexes are famous for a wide array of chemotherapeutic effects. The current study was designed to synthesize and evaluate unexplored chemotherapeutic effects of Cu (II) and Nickel (II) complexes of the non-steroidal anti-inflammatory drug diclofenac. Nickel complex exhibited significant leishmanicidal activity against Lieshmania major, while the copper complex was found to possess low activity against the same pathogen. Both of the complexes revealed low antibacterial activities and were interestingly failed to produce any considerable antimalarial activity against Plasmodium falciparum 3D7. Selective leishmanicidal activities of Nickel (II) complex of diclofenac needs further improvement to be developed as potential new metal-based leishmanicidal agent. |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/19921 |
| ISSN: | 0253-5106 |
| Appears in Collections: | Issue 04 |
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| ViewByVolume.aspx?v=8&i=VOLUME%2032,%20NO4,%20AUG%202010.htm | 147 B | HTML | View/Open |
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