Compettition of Aluminium on Iron Binding Site in the Biological System

Abstract

Aluminum toxicity has been recognized in many ways, when exposure to heavy metals is prolonged, renal function is limited or a previously accumulated bone burden is released in stress and illness. Aluminum is generally found in +3 oxidation state, so sometimes it competes for the binding sites of Fe(III) in the biological system. If the concentration of Aluminum exceeds above the normal, it inhibits the absorption of Iron and Iron deficiency leads to diseases such as Parkinson's and Alzheimer. The complex formations of Al(III) and Fe(III) with salicylic hydroxamate were studied potentiometrically at different temperatures and data were subjected to computer programs. The stability constant (log β) values and thermodynamic stabilities were calculated. It was found that salicylic hydroxamate forms 1:1 complex at pH 3 and 1: 2 complex at pH 4 with Al(III) and Fe(III), respectively. The stability constant (log β) and thermodynamic stabilities of Al(III) salicylic hydroxamate complexes are close to Fe(III) salicylic hydroxamate complexes.