SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDIES OF 2-(4-NITROPHENYLAMINO-CARBONYL)BENZOIC ACID AND ITS COMPLEXES WITH CR(III), CO(II), NI(II), CU(II) AND ZN(II)

Abstract

Cr(III), Co(II), Ni(II), Cu(II) and Zn(II) complexes of 2-(4-Nitrophenylaminocarbo-nyl)benzoic acid were synthesized and characterized on the basis of physical, analytical and spectroscopic data. The ligands, as well as its metal complexes were checked for their in-vitro antimicrobial activity against three bacterial strains, Mycobacterium smegmatis, Escherichia coli, Pseudomonas aeuroginosa, and three fungal strains, Nigrospora oryzae, Aspergillus niger and Candida albicans. Disc diffusion method and Tube diffusion test were used for antibacterial and antifungal activities, respectively. The synthesized complexes only show significant antifungal activity but inactive for antibacterial, however, in general, the metal complexes were found to be more active against antimicrobial activities as compared to their uncomplexed ligand.