Synthesis, Characterization and in vitro Antibacterial Studies of Ternary Complexes using Quinolone Antibiotics as Primary Ligand

Abstract

Some new first row transition metal ternary complexes of quinolone antibiotics (Levofloxacin, Moxifloxacin) and 1,10-phenenthroline were prepared and characterized on the basis of UV-Vis spectroscopy, IR spectral data, magnetic moment, elemental analysis and conductometric measurements. Ligands were found to be bidentate in nature and elemental analysis data revealed [MLL¢´] configuration for all metal complexes. (Where L is respective quinolone antibiotic and L¢ is 1,10-phenenthroline). Conductometric measurements suggested electrolytic nature of all metal complexes. All the synthesized metal complexes were evaluated for their in vitro antibacterial and antifungal activity against three bacterial species, Escherichia Coli (Gram -ve), Mycobacterium smegmatis (Gram +ve), Pseudomonas aeuroginosa (Gram -ve) and three fungal species, Nigrospora oryzae, Aspergillus niger and Candida albicans respectively. All the metal complexes were found to have appreciable antimicrobial activity.