A Facile Multi Component Synthesis of Some Functionalized Chromenes and Spiroindole Derivatives using DABCO as an Efficient Catalyst

Abstract

Chromene and spirocyclic 2-oxindole derivatives were readily synthesized in good yields via a one-pot three-component reaction involving Knoevenagel condensation of aromatic aldehyde or isatin with an active methylene reagent then the intermediate was reacted with another different active methylene reagent via a DABCO-catalysed Michael addition to yield the main products. Some advantages of this protocol are good yields, use of available catalysts, simple workup procedure and short reaction times. All synthesized products were characterized by FT-IR, 1H- and 13C-NMR spectroscopy.