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Title: | Spectrophotometric Determination of Diazepam |
Authors: | WASEEM ASGHAR KHAN NARJIS NAZ NAVEED ASLAM DOGER NAEEM ASGHAR KHAN NADEEM ASGHAR KHAN |
Keywords: | Diazepam Ninhydrin Spectrophotometric Determination |
Issue Date: | 20-Jun-2012 |
Publisher: | HEJ Research Institute of Chemistry, University of Karachi, Karachi. |
Citation: | KHAN, N. A., Naz, N., KHAN, N. A., DOGER, N. A., & KHAN, W. A. (2012). Spectrophotometric Determination of Diazepam. Journal of the Chemical Society of Pakistan, 34(6), 536. |
Abstract: | Diazepam reacts with ninhydrin at pH range 12-12.5 to give a violet color having maximum absorbance at 530 nm wavelength. The reaction is specific for diazepam and provides a basis for its spectrophotometric determination. The color reaction obeys Beer’s law from 0.1 to 2 mg/10 mL of diazepam. Coefficient of variation and confidence limit determination are 0.06 and 0.0041%, respectively. The relative standard deviation is 1.5%. The quantitative assessments of tolerable amount of other drugs have also been studied |
URI: | http://142.54.178.187:9060/xmlui/handle/123456789/19998 |
ISSN: | 0253-5106 |
Appears in Collections: | Issue 03 |
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