Α-Chymotrypsin and Urease Inhibitory Activity of   Diversolides C, D and E from the Roots of Ferula Diversivittata

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Title:	Α-Chymotrypsin and Urease Inhibitory Activity of Diversolides C, D and E from the Roots of Ferula Diversivittata
Authors:	SALEHA SULEMAN KHAN AJMAL KHAN BISHNU P. MARASINI NIKHAT SABA VIQAR UDDIN AHMAD MEHRDAD IRANSHAHI SEYYED TAHMINEH HOSSEINI MUHAMMAD IQBAL CHOUDHARY
Keywords:	Ferula diversivittata α-chymotrypsin , urease, diversolide
Issue Date:	20-Jun-2012
Publisher:	HEJ Research Institute of Chemistry, University of Karachi, Karachi.
Citation:	Khan, S. S., Khan, A., Marasini, B. P., Saba, N., Ahmad, V. U., Iranshani, M., ... & Choudhary, M. I. (2012). (alpha)-Chymotrypsin and Urease Inhibitory Activity of Diversolides C, D and E from the Roots of Ferula Diversivittata. Journal of the Chemical Society of Pakistan, 34(3).
Abstract:	Sesquiterpene lactone derivatives, diversolides-C (giferolide) (1), -D (malafilin) (2), and -E (fegvolide) (3), isolated from the roots of Ferula diversivittata, Regel. & Schmalh, were evaluated for α-chymotrypsin and urease inhibition activities. Diversolide-E (3) was found to be a moderate inhibitor against both enzymes while all others were found to be inactive. The IC₁₅₀ ± SEM values of 3 were 388.2 ± 1.7 µM, and 116.0 ± 4.8 µM for α-chymotrypsin and urease, respectively.
URI:	http://142.54.178.187:9060/xmlui/handle/123456789/20026
ISSN:	0253-5106
Appears in Collections:	Issue 03

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