Synthesis, Analytical and Antibacterial Studies of N-[4-(phenyliminomethyl)phenyl]acetamide 0.67-hydrate and its Complexes with Manganese (II), Cobalt (II) and Nickel (II)

Abstract

The Schiff base (N-[4-(Phenyliminomethyl)phenyl]acetamide 0.67-hydrate) was prepared from 4-acetoamino benzaldehyde and aniline by refluxing the two in ethanolic solution. The metal complexes of Mn (II), Co (II) and Ni (II), were prepared by mixing and refluxing methanolic solutions of MnCl2, CoCl2 and NiCl2 with N-[4- (Phenyliminomethyl)phenyl]acetamide 0.67-hydrate. Metal Schiff base complexes were prepared and characterized by using different techniques, such as; infrared and atomic absorption spectroscopy. Octahedral geometry was proposed for synthesized metal complexes by comparing theoretical and estimated metal ligand ratio. All the synthesized compounds were tested for their antibacterial activity against Staphylococcus epidermidis, Escherichia coli and Staphylococcus aureus bacteria. Schiff base itself was inactive against these bacteria whereas its complexes with Mn (II), Co (II) and Ni (II) have remarkable action against these bacteria, indicating that they can be used as bactericidal agents.