Serum Magnesium and 25-Hydroxy Cholecalciferol in Premenstrual Syndrome during Luteal Phase

Abstract

BACKGROUND: Premenstrual syndrome (PMS) is a recurrent cyclic disorder of cyclical changes in the sexual hormones. It is characterized by emotional, mental and physical symptoms, however pathophysiology is largely unknown. Treatment with drugs like antidepressants, oral contraceptives, GRH agonist has been tried. Recently it has been shown that the levels of 25-hydroxyvitamin D3 and electrolytes such as magnesium have much importance in controlling the symptoms of PMS. OBJECTIVE: To determine serum magnesium and 25-hydroxy cholecalciferol (25-OH-D3) in Premenstrual syndrome (PMS) during luteal phase. METHODOLOGY: This comparative study was conducted at the Department of Gynecology and Obstetrics, Isra University Hospital during June-December 2013. Unmarried female (n=85) aged 18-28 years were selected through non-probability purposive sampling and divided into controls and those having premenstrual syndrome (PMS). 25-hydroxy cholecalciferol (25-OH-D3) was estimated by ARCHITECT I 1000 system and serum magnesium by DiaSys Merck system. Data was analyzed on SPSS version 21.0. Significant p-value was taken at ≤ 0.05. RESULTS: Vitamin 25-OH-D3 was found very low (14.88 ±SD2.39) in cases of PMS, as compared to control (26.20 ±SD4.30) and difference was statistically significant (p=0.0001). Level of Vitamin 25-OH-D3 as low as 8 ng/dl was noted in PMS cases. Serum Mg++ was significantly differs between PMS cases and controls 1.72 ±0.31 vs. 1.84 ±0.12 ng/dl (p=0.02). Vitamin 25-OH-D3 showed positive correlation with serum Mg++ levels (r=0.24, p=0.02). CONCLUSION: Serum magnesium and 25-hydroxychlecalciferol are low with positive correlation in female having premenstrual syndrome.