Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/12825
Title: In-vivo and in-vitro studies to investigate the anti-diabetic mechanisms underlying Moringa oleifera leaf ethanol extracts
Authors: Muhammad Irfan, Hafiz
Zaini Asmawi, Mohd
Abdul Karim Khan, Nurzalina
Alamgeer
Bashir, Sajid
Rasool, Zahid
ur-Rehman, Shafiq
Riaz, Humayun
Keywords: α-Amylase
α-glucosidase
glucose-6-phosphate
monocyte chemoattractant Protein-1
Moringa oleifera
skeletal muscle
Issue Date: 6-May-2020
Publisher: Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi.
Citation: Irfan, H. M., Asmawi, M. Z., Khan, N. A. K., Alamgeer, Bashir, S., Rasool, Z., ... & Riaz, H. (2020). In-vivo and in-vitro studies to investigate the anti-diabetic mechanisms underlying Moringa oleifera leaf ethanol extracts. Pakistan Journal of Pharmaceutical Sciences, 33(3), 1261-1270.
Abstract: Obesity, insulin resistance and cardiovascular complications are endemic global health diseases due to ingestion of high carbohydrate. To prevent such health complications, this study was conducted to report another appealing option that can prevent postprandial hyperglycemia. For in vivo studies, 95% ethanol (v/v) extract of Moringa oleifera and its butanol fraction were given orally once a day for 14-days to streptozotocin-induced diabetic rats. The blood samples were collected to determine plasma insulin, monocyte chemoattractant protein-1 (MCP-1) and glucose-6phosphate (G6P) level. α-amylase and α-glucosidase enzyme kinetics against fixed concentrations of samples (100 µg/mL) was conducted. The M. oleifera ethanol (v/v) extract at 1000 and 500 mg/kg and butanol fraction at 500 mg/kg dose raised the level of G6P and lowered MCP-1 level significantly but failed to increase the level of insulin significantly. The results also indicated non-competitive inhibition of α-amylase, α-glucosidase and a significant increase in glucose uptake by rectus abdominus muscle.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/12825
ISSN: 1011-601X
Appears in Collections:Issue 1

Files in This Item:
File Description SizeFormat 
11-SUP-1385.htm148 BHTMLView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.