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http://142.54.178.187:9060/xmlui/handle/123456789/12972| Title: | In vitro antiglycation and antioxidant properties of benzophenone thiosemicarbazones |
| Authors: | Arshia, Arshia Abbasi, Sanaullah Rasheed, Saima AJ Khan, Jalaluddin Muhammad Saad, Syed Mohammed Khan, Khalid Choudhary, M Iqbal |
| Keywords: | Benzophenone thiosemicarbazone advanced glycation end products (AGEs) antioxidant diabetes structure-activity relationship (SAR) |
| Issue Date: | 19-May-2020 |
| Publisher: | Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. |
| Citation: | Abbasi, S., Rasheed, S., Khan, J. A., Saad, S. M., Khan, K. M., & Choudhary, M. I. (2020). In vitro antiglycation and antioxidant properties of benzophenone thiosemicarbazones. Pakistan Journal of Pharmaceutical Sciences, 33(3), 1147-1154. |
| Abstract: | Fifteen benzophenone thiosemicarbazones were synthesized and their in vitro antiglycation activity was evaluated. The most active compound 2 (IC50 = 118.15±2.41μM) showed two folds potent activity than the standard, rutin (IC50 = 294.5±1.5μM). Compounds 1 and 3-7 showed good to moderate antiglycation activity in the range of 204.14 - 488.54μM. These compounds were also evaluated for antioxidant activity. Their structure-activity relationships have been developed. The results reveal the potential of these compounds as leads for further studies towards the development of antidiabetic drugs. |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/12972 |
| ISSN: | 1011-601X |
| Appears in Collections: | Issue 3 |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Paper%2031.htm | 133 B | HTML | View/Open |
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