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Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/12972
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dc.contributor.authorArshia, Arshia-
dc.contributor.authorAbbasi, Sanaullah-
dc.contributor.authorRasheed, Saima-
dc.contributor.authorAJ Khan, Jalaluddin-
dc.contributor.authorMuhammad Saad, Syed-
dc.contributor.authorMohammed Khan, Khalid-
dc.contributor.authorChoudhary, M Iqbal-
dc.date.accessioned2022-10-12T03:43:30Z-
dc.date.available2022-10-12T03:43:30Z-
dc.date.issued2020-05-19-
dc.identifier.citationAbbasi, S., Rasheed, S., Khan, J. A., Saad, S. M., Khan, K. M., & Choudhary, M. I. (2020). In vitro antiglycation and antioxidant properties of benzophenone thiosemicarbazones. Pakistan Journal of Pharmaceutical Sciences, 33(3), 1147-1154.en_US
dc.identifier.issn1011-601X-
dc.identifier.urihttp://142.54.178.187:9060/xmlui/handle/123456789/12972-
dc.description.abstractFifteen benzophenone thiosemicarbazones were synthesized and their in vitro antiglycation activity was evaluated. The most active compound 2 (IC50 = 118.15±2.41μM) showed two folds potent activity than the standard, rutin (IC50 = 294.5±1.5μM). Compounds 1 and 3-7 showed good to moderate antiglycation activity in the range of 204.14 - 488.54μM. These compounds were also evaluated for antioxidant activity. Their structure-activity relationships have been developed. The results reveal the potential of these compounds as leads for further studies towards the development of antidiabetic drugs.en_US
dc.language.isoenen_US
dc.publisherKarachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi.en_US
dc.subjectBenzophenoneen_US
dc.subjectthiosemicarbazoneen_US
dc.subjectadvanced glycation end products (AGEs)en_US
dc.subjectantioxidanten_US
dc.subjectdiabetesen_US
dc.subjectstructure-activity relationship (SAR)en_US
dc.titleIn vitro antiglycation and antioxidant properties of benzophenone thiosemicarbazonesen_US
dc.typeArticleen_US
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