In vitro antiglycation and antioxidant properties of benzophenone thiosemicarbazones

Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/12972

Title:	In vitro antiglycation and antioxidant properties of benzophenone thiosemicarbazones
Authors:	Arshia, Arshia Abbasi, Sanaullah Rasheed, Saima AJ Khan, Jalaluddin Muhammad Saad, Syed Mohammed Khan, Khalid Choudhary, M Iqbal
Keywords:	Benzophenone thiosemicarbazone advanced glycation end products (AGEs) antioxidant diabetes structure-activity relationship (SAR)
Issue Date:	19-May-2020
Publisher:	Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi.
Citation:	Abbasi, S., Rasheed, S., Khan, J. A., Saad, S. M., Khan, K. M., & Choudhary, M. I. (2020). In vitro antiglycation and antioxidant properties of benzophenone thiosemicarbazones. Pakistan Journal of Pharmaceutical Sciences, 33(3), 1147-1154.
Abstract:	Fifteen benzophenone thiosemicarbazones were synthesized and their in vitro antiglycation activity was evaluated. The most active compound 2 (IC50 = 118.15±2.41μM) showed two folds potent activity than the standard, rutin (IC50 = 294.5±1.5μM). Compounds 1 and 3-7 showed good to moderate antiglycation activity in the range of 204.14 - 488.54μM. These compounds were also evaluated for antioxidant activity. Their structure-activity relationships have been developed. The results reveal the potential of these compounds as leads for further studies towards the development of antidiabetic drugs.
URI:	http://142.54.178.187:9060/xmlui/handle/123456789/12972
ISSN:	1011-601X
Appears in Collections:	Issue 3

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