ANXIOLYTIC EFFECT OF TRIBULUS TERRESTRIS IN AN OPEN FIELD TEST AT DIFFERENT DOSES

Abstract

Anxiety is a mental condition characterized by symptoms of agitation that impairs the life of a person. Available anxiolytics have variable efficacy which emphasizes the need of newer anxiolytic agents. To explore newer anxiolytics herbal medicines are the first approach of drug discovery. The current study was designed to detect the anxiolytic effect of methanolic extract of seeds of Tribulus terrestris. The anxiety model used was open field test. The selected doses were 50mg/Kg, 100mg/Kg and 200mg/Kg and standard drugs Diazepam 1 mg/Kg and Buspirone 5mg/Kg were administered orally in albino mice. The results have shown that it possess significant anxiolytic activity at dose 100mg/Kg as compared to control and insignificant effects compared to diazepam and buspirone. For exact mechanism and complete CNS effects, further studies should be performed on seeds of T. terrestris