Effect of Corn Silk Extract on Renal Functions in Acetaminophin Induced Nephrotoxicity in Mice

Abstract

Aim: To evaluate the effects of corn silk on renal functions in acetaminophin induced nephrotoxicity Study design: Experimental Study. Settings: Anatomy Department. University of Health & Sciences Lahore. FromFebruary,2012 to February, 2013. Methods: Twenty seven male albino mice of age 6-8 weeks and weight 30 ± 5 gm were used. The control Group A wastreated with singleinjection of 16.6ml/kg normal saline on day one of the study via intraperitoneal route and was sacrificed on day ten. Group B was treated with single intraperitoneal injection of acetaminophen (600 mg/kg) and was sacrificed after 2 days. Group C was administered single intraperitoneal injection of acetaminophen (600 mg/kg) on day oneof the experiment followed by theoral gavage of corn silk (CS) extract 400 mg/kg for next 8 days and then sacrificed on day ten. For blood samplingCardiac puncture was performed. Results: A statistically significant raised (p < 0.005) levels of serum urea and creatinine in group B wereobserved. In groups C serum urea and creatinine levels were significantly reduced. Conclusion: The results of present study suggest CS extract provides protection against acetaminophen induced rephrotoxicity.