Please use this identifier to cite or link to this item:
http://localhost:80/xmlui/handle/123456789/13777
Title: | Synthesis of (4R)-thiazolidine carboxylic acid and evaluation of antioxidant potential |
Authors: | Begum, Nasreen Anis, Itrat Saeed, Syed Muhammad Ghufran Ashraf, Seema Choudhary, M. Iqbal |
Keywords: | Antioxidant activity DPPH L-cysteine free radical scavenging (4R) Thiazolidine carboxylic acid |
Issue Date: | 16-Mar-2020 |
Publisher: | Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi |
Abstract: | We report here the synthesis as well as antioxidant activity of a series of 2-aryl thiazolidine-4-carboxylic acids, including two novel derivatives. They were synthesized by nucleophilic cyclic condensation of L-cysteine hydrochloride with a range of aromatic aldehydes. Their in vitro antioxidant activity was evaluated by DPPH radical scavenging assay. It was observed that the aromatic substituent at C-2 of thiazolidine ring effects the antioxidant potential of the thiazolidine derivatives. The nature and position of the substituents on aromatic ring were correlated with antioxidant activity. Compounds with -OCH3 group on aromatic ring showed a better radical scavenging property than the other groups such as -Cl, -F, and -NO2. The presence of phenyl ring thus enhanced radical scavenging activity. |
URI: | http://142.54.178.187:9060/xmlui/handle/123456789/13777 |
ISSN: | 1011-601X |
Appears in Collections: | Issue 2 |
Files in This Item:
File | Description | Size | Format | |
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Paper-10.htm | 131 B | HTML | View/Open |
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