Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/13777
Title: Synthesis of (4R)-thiazolidine carboxylic acid and evaluation of antioxidant potential
Authors: Begum, Nasreen
Anis, Itrat
Saeed, Syed Muhammad Ghufran
Ashraf, Seema
Choudhary, M. Iqbal
Keywords: Antioxidant activity
DPPH
L-cysteine
free radical scavenging
(4R) Thiazolidine carboxylic acid
Issue Date: 16-Mar-2020
Publisher: Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi
Abstract: We report here the synthesis as well as antioxidant activity of a series of 2-aryl thiazolidine-4-carboxylic acids, including two novel derivatives. They were synthesized by nucleophilic cyclic condensation of L-cysteine hydrochloride with a range of aromatic aldehydes. Their in vitro antioxidant activity was evaluated by DPPH radical scavenging assay. It was observed that the aromatic substituent at C-2 of thiazolidine ring effects the antioxidant potential of the thiazolidine derivatives. The nature and position of the substituents on aromatic ring were correlated with antioxidant activity. Compounds with -OCH3 group on aromatic ring showed a better radical scavenging property than the other groups such as -Cl, -F, and -NO2. The presence of phenyl ring thus enhanced radical scavenging activity.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/13777
ISSN: 1011-601X
Appears in Collections:Issue 2

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