PHARMACOKINETICS OF CIPROFLOXACIN IN NORMAL RABBITS AND CHANGES OBSERVED IN INDUCED DEHYDRATED STATE

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Title:	PHARMACOKINETICS OF CIPROFLOXACIN IN NORMAL RABBITS AND CHANGES OBSERVED IN INDUCED DEHYDRATED STATE
Authors:	BASHIR, SAJID JAMSHAID, MOHAMMAD AHMAD, BASHIR IQBAL, JAVEID
Keywords:	Pharmacokinetics ciprofloxacin plasma concentration dehydrated rabbits
Issue Date:	4-Jul-2008
Publisher:	Karachi:Pakistan Journal of Botany, Botanical Garden, University of Karachi
Citation:	Bashir, S., Jamshaid, M., Ahmad, B., & Iqbal, J. (2008). Pharmacokinetics of ciprofloxacin in normal rabbits and changes observed in induced dehydrated state. Pakistan Journal of Pharmaceutical Sciences, 21(3), 225-230.
Abstract:	The pharmacokinetics of ciprofloxacin following oral administration of a single dose of 20mg/Kg body weight was investigated in normal rabbits and changes were observed in water-deprived rabbits. High performance liquid chromatographic method was employed for the determination of plasma concentration of ciprofloxacin. The mean plasma concentration and AUC (0-t) and AUC (0-inf) were significantly different between normal and dehydrated rabbits (P<0.05), but the absorption rate, distribution rate, and elimination rate did not show any statistically significant difference. The results reflect a need for monitoring toxicity of ciprofloxacin in the water-deprived condition.
URI:	http://142.54.178.187:9060/xmlui/handle/123456789/14167
ISSN:	1011-601X
Appears in Collections:	Issue 3

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