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http://142.54.178.187:9060/xmlui/handle/123456789/14167| Title: | PHARMACOKINETICS OF CIPROFLOXACIN IN NORMAL RABBITS AND CHANGES OBSERVED IN INDUCED DEHYDRATED STATE |
| Authors: | BASHIR, SAJID JAMSHAID, MOHAMMAD AHMAD, BASHIR IQBAL, JAVEID |
| Keywords: | Pharmacokinetics ciprofloxacin plasma concentration dehydrated rabbits |
| Issue Date: | 4-Jul-2008 |
| Publisher: | Karachi:Pakistan Journal of Botany, Botanical Garden, University of Karachi |
| Citation: | Bashir, S., Jamshaid, M., Ahmad, B., & Iqbal, J. (2008). Pharmacokinetics of ciprofloxacin in normal rabbits and changes observed in induced dehydrated state. Pakistan Journal of Pharmaceutical Sciences, 21(3), 225-230. |
| Abstract: | The pharmacokinetics of ciprofloxacin following oral administration of a single dose of 20mg/Kg body weight was investigated in normal rabbits and changes were observed in water-deprived rabbits. High performance liquid chromatographic method was employed for the determination of plasma concentration of ciprofloxacin. The mean plasma concentration and AUC (0-t) and AUC (0-inf) were significantly different between normal and dehydrated rabbits (P<0.05), but the absorption rate, distribution rate, and elimination rate did not show any statistically significant difference. The results reflect a need for monitoring toxicity of ciprofloxacin in the water-deprived condition. |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/14167 |
| ISSN: | 1011-601X |
| Appears in Collections: | Issue 3 |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Paper-4.htm | 142 B | HTML | View/Open |
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