Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/14259
Title: DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETERIC METHOD FOR SIMULTANEOUS DETERMINATION OF SIMVASTATIN AND EZETIMIBE IN TABLET FORMULATIONS
Authors: BALAJI, S
SUNITHA, A
Keywords: Simvastatin (SMV)
Ezetimibe (EZE)
methanol
ultraviolet spectrophotometry
absorption ratio method
Issue Date: 4-Oct-2010
Publisher: Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi
Citation: Balaji, S., & Sunitha, A. (2010). Development and validation of spectrophotometeric method for simultaneous determination of simvastatin and ezetimibe in tablet formulations. Pakistan Journal of Pharmaceutical Sciences, 23(4), 375-379.
Abstract: A versatile, accurate, precise and economic method for simultaneous determination of simvastatin and ezetimibe in fixed dose combination products was developed. The absorbance values at 236 nm and 234 nm of over line spectrum was used for the estimation of simvastatin and ezetimibe, respectively without mutual interference. This method obeyed Beer’s law in the concentration range of 4 – 16 µg /ml for simvastatin and 4- 16 µg /ml for ezetimibe. The results of analyses have been validated statistically for linearity, accuracy and precision of the proposed method.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/14259
ISSN: 1011-601X
Appears in Collections:Issue 04

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