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http://142.54.178.187:9060/xmlui/handle/123456789/14409| Title: | REACTIONS OF PHTHALIMIDES WITH 1-METHYLETHYLAMINE: ANALGESIC AND ANTI-INFLAMMATORY PROPERTIES OF RESULTING CARBOXAMIDES |
| Authors: | OKUNROBO, L. O. USIFOH, C. O. OKPO, S. O. |
| Keywords: | Carboxamides synthesis analgesic activity rat paw oedema |
| Issue Date: | 7-Jan-2006 |
| Publisher: | Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi |
| Citation: | Okunrobo, L. O., Usifoh, C. O., & Okpo, S. O. (2006). Reactions of phthalimides with 1-methylethylamine: analgesic and anti-inflammatory properties of resulting carboxamides. Pak. J. Pharm. Sci, 19(1), 28-34. |
| Abstract: | The reaction of phthalimide derivatives (1a-c) with 1-methylethylamine in dimethylformamide (DMF) at room temperature afforded benzamido-N-prop-2-ynyl-2-(2-methylethyl)-carboxamide (3a), benzamido-N-cyclopentyl-2- (2-methylethyl)-car-boxamide (3b) and benzamido-N-benzyl-2-(2-methylethyl)-carboxamide (3c), respectively. In the carrageenan induced paw oedema test for anti-inflammatory activity, 3a (50 mg/kg) decreased the inflammatory response by 55% after 3 hrs while 3b and 3c exhibited significant reduction in the oedema level. The compounds 3a, 3b and 3c exhibited analgesic activities with 3b producing 76% inhibition. The activities were dose – dependent. |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/14409 |
| ISSN: | 1011-601X |
| Appears in Collections: | 2006,Part-1 |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Paper-7.htm | 142 B | HTML | View/Open |
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